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A fearless warrior immune to vampires, Blade (Wesley Snipes) has become a hated enemy of the bloodsucking community, and as they gather in their desert compound, a group of vampires is plotting to eliminate Blade once and for all by turning the mortal community against him. The vampires have concocted a campaign that paints a picture of Blade as a ruthless murderer and has sent the FBI on the vampire hunter's trail, led by the relentless agent Cumberland (James Remar). At the same time, the vampires have brought their founding father, Dracula, back to his undead state, renaming him Drake (Dominic Purcell) and investing him with special powers that allow him to walk unharmed in daylight. After a dangerous encounter with Cumberland, Blade and his ally, Whistler (Kris Kristofferson), form an uneasy alliance with a team of human vampire slayers, the Nighstalkers, led by Hannibal King (Ryan Reynolds), and Whistler's daughter, Abigail (Jessica Biel).
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