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Anthony Hopkins is Dr. Hannibal Lecter, one of the world's most cunning and feared serial killers, who resurfaces after a decade in hiding to toy with FBI agent Clarice Starling (Julianne Moore). As Starling's career flounders thanks to a drug bust gone wrong, Lecter attempts to elude a greedy Italian police detective (Giancarlo Giannini) who's willing to alert the authorities to his presence in Florence for a price. In the meantime, a maimed but wealthy former victim of Lecter's named Mason Verger (Gary Oldman) plots to get his revenge on the doctor in a most unusual and grisly fashion.
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