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Dr. Anton Rudolph (Robert Englund) is a scientist who has spent years breeding and perfecting the ideal living weapon, a gigantic python that's 60 feet long and can swallow nearly anything in its path. Rudolph is transporting his new creation by air when their plane crashes near a small town and the mutant snake escapes. Rudolph is forced to team up with Bart Parker (Casper Van Dien), a military security expert, to round up the snake, but in the meantime, more than a few locals are pointing fingers at eccentric John Cooper (Frayne Rosenoff), who has a fondness for snakes and a bad reputation with the local cops.
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